In the living room, pine beams highlight the ceiling, and the French doors feature curtains of a Duralee velvet trimmed with an ikat by Kravet. The mesquite bookshelves were custom made, the Fisher Weisman–designed daybed and sofa are upholstered in a Gretchen Bellinger linen velvet, and the antique Moroccan rugs were purchased in Marrakech.

San Francisco–based interior designers Andrew Fisher (left) and Jeffry Weisman, of the firm Fisher Weisman, at Casa Acanto, their retreat in San Miguel de Allende, Mexico.

The former tannery, built in the 18th century, opens onto multiple terraces as well as the sala abierta.

Fisher designed the dining room’s light fixture, fashioned of seashells, green glass, and mother-of-pearl, and he also made the gold-leafed paintings; both the table, which has a walnut top and a hand-carved mahogany base, and the chairs are by Fisher Weisman for Michael Taylor Designs. The floor tiles were hand-rubbed with gasoline and tar to create a patina.

Adjoining the main house’s dining room is the sala abierta, or outdoor living room, a favorite spot for entertaining.

The sala abierta’s marble table, conceived by Fisher Weisman and hand-carved in India, is grouped with sofas the duo created for Michael Taylor Designs, with cushions clad in a Duralee fabric.

The tables on the dining terrace are by Fisher Weisman for their new furniture and accessories line, also called Casa Acanto; the Michael Taylor Designs chairs are covered in a Sunbrella fabric.

The kitchen cabinets are sabino and reclaimed pine, and the hood over the Viking range is fronted by a sabino-framed mirror.

The couple devised the kitchen’s frieze as well as the mesquite-and-sabino-wood island, whose bronze legs were sculpted by Fisher.

A watercolor by Fisher hangs over the fireplace in the breakfast room; the chairs are covered in a Rose Cumming linen from Dessin Fournir.

Fisher designed the office’s desk and embellished the Queen Anne chair with shells and black paint.

A watercolor by Fisher is mounted over the master bedroom’s mantel, which is flanked by, from top, a pair of the designer’s pencil drawings of seashells, two of his gilded tapestries, and a set of antique embroidery panels. The Fisher Weisman–designed door is made of reclaimed pine beams connected with steel studs; the bed is dressed in Frette linens, and the bedside lamp is a 19th-century Italian piece that once resided at Hearst Castle.

The master bath’s pendant lights are by Jonathan Browning Studios, and the sink fittings are a custom design by Fisher Weisman.

The pair created the room’s tiered copper light fixture, which also serves as a tub filler for the copper bath, crafted by a Mexican artisan.

In a guest room, the house’s blue-and-white motif continues with curtains made of a Kravet fabric and, on the adjacent wall, two antique ceiling panels from a Japanese temple.

The tile in a guest bath was produced in the nearby city of Dolores Hidalgo.

The designers built the guest casita to host their frequent visitors.

The roof terrace of the guest casita provides stunning views of the town and its surroundings; the teak sofa and chairs are by Michael Taylor Designs, with cushions covered in a Sunbrella fabric.

Photography by Simon Watson